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Another promising property of Madecassoside is that it seems to inhibit UV-induced melanin synthesis (test formula with 0.05% MA, used twice a day on 23 volunteers for 8 weeks), making it a great active for hyperpigmentation-prone skin

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The clinical utility of conventional copper chelators is limited by dose-dependent toxicities, primarily stemming from systemic copper deficiency and off-target chelation of essential metals, such as zinc and iron