Autosomal recessive PARK2 mutations, a leading cause of early-onset PD, reduce or eliminate Parkin, impairing mitophagy, causing damaged mitochondria to accumulate, increasing oxidative stress, and triggering dopaminergic neuron death, thus driving PD progression (143)
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If you were to distill it down, they do have other things as well, but if you were to distill it down to what keeps this larger subset of children with autism stuck and we can talk about the more severe cases what keeps them from struggling to socialize, struggling to connect, and if you were to distill that as one of the foundational things, then we ask, well, what causes that
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