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However, I/R can cause myocardial reperfusion injury, which results in myocardial cell death [5]

The research suggests it will still go systemic and may still work

It must be highlighted that rat skeletal muscle TC increases ~ 5070% following 4 weeks of LC supplementation [33, 34], whereas comparable elevation has never been observed in human studies, even after 24 weeks of supplementation [5, 7]