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BioRender ( was used to create the Fig

The eggs are no longer maturing and thus ovulation ceases

However, creatine status cannot be inferred from SAM alone and should be interpreted in the wider clinical and metabolic context

We observed that cells from aged killifish, while having a smaller fraction of dividing cells compared to cells from young killifish, had a stronger signal for DNA damage (H2AX) (Extended Data Fig